All Phenotypes Slc17a7<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc17a7⁺
wild type
MGI:3049591

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slc17a7^tm1Bros/Slc17a7⁺	involves: 129 * C57BL/6N	MGI:3718198
ht2	Slc17a7^tm1Lex/Slc17a7⁺	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5141086
ht3	Slc17a7^{tm1.1(cre)Hze}/Slc17a7⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5508525

Allelic Composition	Slc17a7^tm1Bros/Slc17a7⁺
Genetic Background	involves: 129 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a7^tm1Bros mutation (0 available); any Slc17a7 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal long-term object recognition memory ( J:118618 )

• 24 hours following the sample phase, mice do not discriminate the novel object whereas wild-type mice do

behavioral despair ( J:118618 )

• in a forced-swimming test, mice spend more time immobile compared to wild-type mice

increased anxiety-related response ( J:118618 )

• mice are more anxious in a light-dark exploration test in that mice spend less time in the white area and crossed fewer lines compared to wild-type mice

nervous system

abnormal nervous system physiology ( J:118618 )

• GABA levels in the frontal cortex and dorsal hippocampus are reduced

Allelic Composition	Slc17a7^tm1Lex/Slc17a7⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a7^tm1Lex mutation (2 available); any Slc17a7 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:174414 )

• field EPSP responses increase faster with increased signal strength than for controls

• increased response with increased signal strength fails to reach the level seen for controls

reduced long-term potentiation ( J:174414 )

• reduced LTP as a result of theta burst stimulation

• controls demonstrate a saturated response after the second series while homozygotes continue to show small increases

• maintenance is at a lower level than in controls

behavior/neurological

abnormal inhibitory learning ( J:174414 )

• initial spatial learning ability in a Morris water maze is similar to controls

• slower in relearning platform location when the platform is moved to a different quadrant

Allelic Composition	Slc17a7^{tm1.1(cre)Hze}/Slc17a7⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a7^{tm1.1(cre)Hze} mutation (2 available); any Slc17a7 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:146821 )

• mice are viable and fertile with no gross physical or behavioral abnormalities

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