All Phenotypes Prickle1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prickle1⁺
wild type
MGI:3049324

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prickle1^tm1Nue/Prickle1⁺	B6.Cg-Prickle1^tm1Nue	MGI:4941932
ht2	Prickle1^em1Yzou/Prickle1⁺	C57BL/6-Prickle1^em1Yzou	MGI:6890374
ht3	Prickle1^m2Ingm/Prickle1⁺	C57BL/6-Prickle1^m2Ingm	MGI:4941935
ht4	Prickle1^m1Ingm/Prickle1⁺	involves: C57BL/6	MGI:4941933
cx5	Prickle1^tm1Nue/Prickle1⁺ Vangl2^Lp/Vangl2⁺	involves: C57BL/6J * CBA * LPT/LeJ	MGI:4356109

Allelic Composition	Prickle1^tm1Nue/Prickle1⁺
Genetic Background	B6.Cg-Prickle1^tm1Nue

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^tm1Nue mutation (1 available); any Prickle1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:169136 )

• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

nervous system

abnormal seizure response to electrical stimulation ( J:169136 )

• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

Allelic Composition	Prickle1^em1Yzou/Prickle1⁺
Genetic Background	C57BL/6-Prickle1^em1Yzou

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^em1Yzou mutation (0 available); any Prickle1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:321396 )

• mice exhibit shorter latencies to Pentylenetrazole (PTZ)-induced tonic-clonic seizure indicating reduced seizure threshold

• seizure susceptibility is enhanced more than in homozygous mice

abnormal spatial reference memory ( J:321396 )

• in the Barnes maze task, mice spend similar time in the target quadrant and other quadrants unlike controls that spend more time in the target quadrant, indicating a mild deficit in spatial memory

• however, mice show no differences from wild-type mice in novel object recognition

abnormal social investigation ( J:321396 )

• mice show deficits in sociability in the three-chamber social interaction task

• however, mice show normal social recognition memory in the three-chamber social novelty task

• mice show no differences in anxiety in the open field arena, elevated plus maze, or light-dark transition tasks

nervous system

increased susceptibility to pharmacologically induced seizures ( J:321396 )

• mice exhibit shorter latencies to Pentylenetrazole (PTZ)-induced tonic-clonic seizure indicating reduced seizure threshold

• seizure susceptibility is enhanced more than in homozygous mice

abnormal excitatory synapse morphology ( J:321396 )

• mice show a 35% reduction in the number of excitatory glutamatergic synapses in the hippocampus in adults

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder	DOID:0060041		J:321396
progressive myoclonus epilepsy 1B	DOID:0111448	OMIM:612437	J:321396

Allelic Composition	Prickle1^m2Ingm/Prickle1⁺
Genetic Background	C57BL/6-Prickle1^m2Ingm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^m2Ingm mutation (1 available); any Prickle1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:169136 )

• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

nervous system

abnormal seizure response to electrical stimulation ( J:169136 )

• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice

Allelic Composition	Prickle1^m1Ingm/Prickle1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^m1Ingm mutation (0 available); any Prickle1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:169136 )

nervous system

abnormal seizure response to electrical stimulation ( J:169136 )

Allelic Composition	Prickle1^tm1Nue/Prickle1⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: C57BL/6J * CBA * LPT/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^tm1Nue mutation (1 available); any Prickle1 mutation (33 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic epiblast morphology ( J:151993 )

• nuclei in the epiblast are more spherical and randomly aligned along the apical basal axis

• expression analysis indicates that apical-basal cell polarity is disrupted similar to the phenotype of single homozygous Prickle1 mutant mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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