Phenotypes associated with this allele

• Allele Symbol: Ppp2r2a⁺
• Allele Name: wild type
• Allele ID: MGI:3049315
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ppp2r2a^tm1b(KOMP)Wtsi/Ppp2r2a^+	C57BL/6N-Ppp2r2a^tm1b(KOMP)Wtsi/Nju	MGI:6263217
ht2	Ppp2r2a^igt10/Ppp2r2a^+	involves: C3H/HeH * C57BL/6J	MGI:6160733
cx3	Insr^tm1Dac/Insr^+ Ppp2r2a^igt10/Ppp2r2a^+	involves: 129S4/SvJae * C3H/HeH * C57BL/6J	MGI:6160731

Genotype
MGI:6263217

ht1

• Allelic Composition: Ppp2r2a^{tm1b(KOMP)Wtsi}/Ppp2r2a⁺
• Genetic Background: C57BL/6N-Ppp2r2a^{tm1b(KOMP)Wtsi}/Nju
• Cell Lines: EPD0328_1_G07

Data Sources

IMPC Data for Ppp2r2a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - MARC

decreased body length ( J:211773 )

IMPC - MARC

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - MARC

decreased bone mineral content ( J:211773 )

IMPC - MARC

decreased bone mineral density ( J:211773 )

IMPC - MARC

Genotype
MGI:6160733

ht2

• Allelic Composition: Ppp2r2a^igt10/Ppp2r2a⁺
• Genetic Background: involves: C3H/HeH * C57BL/6J

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

homeostasis/metabolism

increased circulating insulin level ( J:246319 )

insulin resistance ( J:246319 )

Genotype
MGI:6160731

cx3

• Allelic Composition: Insr^tm1Dac/Insr⁺; Ppp2r2a^igt10/Ppp2r2a⁺
• Genetic Background: involves: 129S4/SvJae * C3H/HeH * C57BL/6J

homeostasis/metabolism

hyperglycemia ( J:246319 )

• mice exhibit elevated plasma glucose levels from 18 weeks

increased circulating insulin level ( J:246319 )

• plasma insulin levels are elevated more than in either single heterozygote

impaired glucose tolerance ( J:246319 )

• mice show impaired glucose tolerance at 12 weeks of age

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

insulin resistance ( J:246319 )

renal/urinary system

increased urine glucose level ( J:246319 )

• mice exhibit glycosuria by 28 weeks of age

behavior/neurological

polydipsia ( J:246319 )

• mice drink more and produce more urine as glycosuria develops

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:246319 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:246319