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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phf6+
wild type
MGI:3049220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Phf6tm1b(EUCOMM)Wtsi/Phf6+ C57BL/6N-Phf6tm1b(EUCOMM)Wtsi/Ics MGI:6263152
ht2
 		Phf6tm1.2Avo/Phf6+ involves: BALB/cJ * C57BL/6 MGI:6507171


Genotype
MGI:6263152
ht1
Allelic
Composition		 Phf6tm1b(EUCOMM)Wtsi/Phf6+
Genetic
Background		 C57BL/6N-Phf6tm1b(EUCOMM)Wtsi/Ics
Cell Lines EPD0103_5_F06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6tm1b(EUCOMM)Wtsi mutation (0 available); any Phf6 mutation (12 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear




Genotype
MGI:6507171
ht2
Allelic
Composition		 Phf6tm1.2Avo/Phf6+
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6tm1.2Avo mutation (0 available); any Phf6 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:276228 )
• mice show an earlier onset of hematopoietic neoplasms that spontaneously occur in wild-type mice
• tumors are localized to the liver, spleen, and/or lymph nodes
• tumors express T-cell, B-cell, or myeloid/erythroid cell surface makers or show aberrant expression of markers from multiple hematopoietic lineages

growth/size/body
decreased body weight ( J:299742 )
• females show reduced body weight by 3 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory