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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nampt+
wild type
MGI:3049176
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		NamptGt(RRT307)Byg/Nampt+ B6.129P2-NamptGt(RRT307)Byg MGI:3772779
ht2
 		Nampttm1.1(KOMP)Vlcg/Nampt+ C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd MGI:5767736
ht3
 		NamptGt(RRR084)Byg/Nampt+ involves: 129P2/OlaHsd * C57BL/6 MGI:5474950


Genotype
MGI:3772779
ht1
Allelic
Composition		 NamptGt(RRT307)Byg/Nampt+
Genetic
Background		 B6.129P2-NamptGt(RRT307)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NamptGt(RRT307)Byg mutation (0 available); any Nampt mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:130534 )
• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide
decreased circulating glucose level ( J:130534 )
• fasted male mice exhibit decreased glucose levels compared to wild-type mice
impaired glucose tolerance ( J:130534 )
• female mice exhibit impaired glucose tolerance compared to male mice and wild-type mice
• however, impaired glucose tolerance is reversed following administration of nicotinamind mononucleotide

endocrine/exocrine glands
decreased insulin secretion ( J:130534 )
• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide




Genotype
MGI:5767736
ht2
Allelic
Composition		 Nampttm1.1(KOMP)Vlcg/Nampt+
Genetic
Background		 C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd
Cell Lines 12136A-F2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nampttm1.1(KOMP)Vlcg mutation (1 available); any Nampt mutation (91 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
hydrocephaly ( J:211773 )
IMPC - UCD




Genotype
MGI:5474950
ht3
Allelic
Composition		 NamptGt(RRR084)Byg/Nampt+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NamptGt(RRR084)Byg mutation (0 available); any Nampt mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:194883 )
• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury
decreased interleukin-6 secretion ( J:194883 )
• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury

homeostasis/metabolism
decreased susceptibility to injury ( J:194883 )
• mice subjected to ventilator-induced lung injury exhibit decreased inflammatory lung injury and lower peak inspiratory pressures at the end of the mechanical ventilation period compared with wild-type mice

hematopoietic system
decreased neutrophil cell number ( J:194883 )
• in the bronchoalveolar lavage fluid of mice subjected to ventilator-induced lung injury




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/04/2024
MGI 6.13 		The Jackson Laboratory