Phenotypes associated with this allele

• Allele Symbol: Mus81⁺
• Allele Name: wild type
• Allele ID: MGI:3049049
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mus81^tm1Raz/Mus81^+	involves: 129P2/OlaHsd	MGI:3050292
ht2	Mus81^tm1Esse/Mus81^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3794045
ht3	Mus81^tm1Esse/Mus81^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5661526

Genotype
MGI:3050292

ht1

• Allelic Composition: Mus81^tm1Raz/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91570 )

• only 50% of heterozygotes survive to 1 year compared to 95% of wild-type littermates

neoplasm

increased adenoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and adenoma of the prostate, bladder, or colon

increased lymphoma incidence ( J:91570 )

• mutants have a non-Hodgkin's lymphoma incidence of 0.97

• 7 out of 33 lymphomas showed metastatic potential

• heterozygous mutants had either B cell (5/12) or T cell (7/12) derived lymphomas

increased carcinoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and ductal carcinoma

cellular

chromosome breakage ( J:91570 )

• T cell metaphase spreads show increased chromosomal abnormalities including a mild propensity for aneuploidy

• mutants display increased sensitivity to mitomycin c induced sister chromatid exchange

Genotype
MGI:3794045

ht2

• Allelic Composition: Mus81^tm1Esse/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

abnormal aorta wall morphology ( J:133703 )

• subtle changes including reduction in translucence of the aortic wall

• accumulation of excess amorphous matrix material between elastic fibers; however, no defect in fiber integrity is seen

abnormal subclavian artery morphology ( J:133703 )

• abnormal ballooning of the proximal right subclavian artery

Genotype
MGI:5661526

ht3

• Allelic Composition: Mus81^tm1Esse/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

cardiovascular system

abnormal aorta morphology ( J:222498 )

• an increase in matrix metalloproteinases activation is seen in both the thoracic aorta and abdominal aorta

abnormal aorta tunica media morphology ( J:222498 )

• aortas show increased medial thickness

abnormal aorta elastic tissue morphology ( J:222498 )

• aortas show signs of elastin breakage and increased deposition of amorphous cell material between the elastin layers

immune system

increased inflammatory response ( J:222498 )

• mice treated with LPS to mimic bacterial infection exhibit increased and prolonged inflammatory response compared to wild-type mice, showing a greater influx of macrophages, dendritic cells, T-cells, and granulocytes

respiratory system

abnormal lung morphology ( J:222498 )

• adult, but not neonatal, lungs show interruptions in the elastin layers

• graded increase in neutrophil elastase activity in the lungs

• an increase in matrix metalloproteinases activation is seen in the lungs

• however, inflammation in the lungs is not seen

overexpanded pulmonary alveolus ( J:222498 )

• alveolar airspace enlargement in adult lungs

emphysema ( J:222498 )

• mice acquire emphysematous changes with age