All Phenotypes Lrp4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp4⁺
wild type
MGI:3048917

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lrp4^tm1.1Pg/Lrp4⁺	involves: C57BL/6N	MGI:6404125
cx2	App^tm1Dbo/App^tm1Dbo Lrp4^tm1Her/Lrp4⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	MGI:5561078

Allelic Composition	Lrp4^tm1.1Pg/Lrp4⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4^tm1.1Pg mutation (1 available); any Lrp4 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone strength ( J:277372 )

• mice show an increase in the work needed to fracture the femur and an increase in the work needed to reach the ultimate tensile strength in a three-point bending analysis, indicating increased bone strength

• however, no changes are seen in trabecular or cortical bone mass and density, in osteoblast, osteocyte, or osteoclast number or surface

Allelic Composition	App^tm1Dbo/App^tm1Dbo Lrp4^tm1Her/Lrp4⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Dbo mutation (4 available); any App mutation (111 available)
Lrp4^tm1Her mutation (1 available); any Lrp4 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:207796 )

• 6 of 45 mice die within 5 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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