Phenotypes associated with this allele

• Allele Symbol: Abcc12⁺
• Allele Name: wild type
• Allele ID: MGI:3048011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Abcc12^em1Yinc/Abcc12^+	involves: C57BL/6J	MGI:8233528

Genotype
MGI:8233528

ht1

• Allelic Composition: Abcc12^em1Yinc/Abcc12⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating bilirubin level ( J:343988 )

• when fed a 1% cholic acid supplemented diet for 14 days increase in total bilirubin levels is greater than in diet matched wild-type controls

liver/biliary system

abnormal bile duct physiology ( J:343988 )

• viability of primary cholangiocytes cultured with cholic acid is reduced at baseline compared to wild-type cells

• primary cholangiocytes show increased sensitivity to increasing concentrations of cholic acid compared to wild-type cells

increased cholangiocyte apoptosis ( J:343988 )

• in response to cholic acid either in vitro or in vivo

growth/size/body

increased susceptibility to weight loss ( J:343988 )

• when fed a 1% cholic acid supplemented diet for 14 days mutant mice show increased weight loss and higher liver/body weight ratio compared to diet matched wild-type controls

cellular

increased cholangiocyte apoptosis ( J:343988 )

• in response to cholic acid either in vitro or in vivo