Phenotypes associated with this allele

• Allele Symbol: Arhgap21⁺
• Allele Name: wild type
• Allele ID: MGI:3047934
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Arhgap21^Gt(RRR629)Byg/Arhgap21^+	B6.129P2-Arhgap21^Gt(RRR629)Byg	MGI:6196212
ht2	Arhgap21^em1(IMPC)J/Arhgap21^+	C57BL/6NJ-Arhgap21^em1(IMPC)J/Mmjax	MGI:6461077

Genotype
MGI:6196212

ht1

• Allelic Composition: Arhgap21^{Gt(RRR629)Byg}/Arhgap21⁺
• Genetic Background: B6.129P2-Arhgap21^{Gt(RRR629)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased megakaryocyte cell number ( J:262703 )

• 2-fold increase in frequency

decreased erythroid progenitor cell number ( J:262703 )

• 2-fold decrease in the bone marrow and spleen

• however, late subtypes of erythroid differentiation is normal

increased megakaryocyte progenitor cell number ( J:262703 )

decreased erythrocyte cell number ( J:262703 )

decreased hemoglobin content ( J:262703 )

thrombocytopenia ( J:262703 )

increased leukocyte cell number ( J:262703 )

• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal

increased neutrophil cell number ( J:262703 )

decreased hematopoietic stem cell number ( J:262703 )

• in the bone marrow

abnormal hematopoietic stem cell physiology ( J:262703 )

• enhanced egress from the bone marrow with reduced fibronectin adhesion

homeostasis/metabolism

increased susceptibility to injury ( J:262703 )

• mice treated with 5-fluorouracil exhibit increased neutrophils likely due to increased hematopoietic stem cells but decreased colonies forming units (CFU-GEMM, combined number of CFU-GM, CFU-G and CFU-M, and BFU-E) in the bone marrow and hematocrit compared with wild-type mice

immune system

increased leukocyte cell number ( J:262703 )

• however, the percentage of B220+ B lymphocytes and T lymphocytes are normal

increased neutrophil cell number ( J:262703 )

Genotype
MGI:6461077

ht2

• Allelic Composition: Arhgap21^em1(IMPC)J/Arhgap21⁺
• Genetic Background: C57BL/6NJ-Arhgap21^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Arhgap21

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - JAX

behavior/neurological

abnormal vocalization ( J:211773 )

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - JAX

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - JAX