Phenotypes associated with this allele

• Allele Symbol: Arhgef12⁺
• Allele Name: wild type
• Allele ID: MGI:3047920
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Arhgef12^tm1b(KOMP)Wtsi/Arhgef12^+	C57BL/6N-Arhgef12^tm1b(KOMP)Wtsi/Tcp	MGI:6288337
cx2	Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd Arhgef12^tm1Sgkd/Arhgef12^+	involves: 129 * C57BL/6J	MGI:5505424

Genotype
MGI:6288337

ht1

• Allelic Composition: Arhgef12^{tm1b(KOMP)Wtsi}/Arhgef12⁺
• Genetic Background: C57BL/6N-Arhgef12^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0838_1_A07

Data Sources

IMPC Data for Arhgef12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:211773 )

♀

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

abnormal heart shape ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - TCP

abnormal embryo size ( J:211773 )

IMPC - TCP

nervous system

increased prepulse inhibition ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:5505424

cx2

• Allelic Composition: Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd; Arhgef12^tm1Sgkd/Arhgef12⁺
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

preweaning lethality, incomplete penetrance ( J:198274 )

• fewer than expected mice are produced