Phenotypes associated with this allele

• Allele Symbol: Cacna1c^tm1Jst
• Allele Name: targeted mutation 1, Jorg Striessnig
• Allele ID: MGI:3047071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1c^tm1Jst/Cacna1c^tm1Jst	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3047384

Genotype
MGI:3047384

hm1

• Allelic Composition: Cacna1c^tm1Jst/Cacna1c^tm1Jst
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:91092 )

• BayK causes depression like behavior as assessed in a forced swimming test

abnormal motor capabilities/coordination/movement ( J:91092 )

• motor function no longer compromised by Bay K

cardiovascular system

abnormal myocardial fiber physiology ( J:91092 )

• dihydropyridine (DHP) binding to heart membranes reduced to insignificant levels

• whole cell currents in cardiomyocytes were normal

• decreased sensitivity to DHP, current only blocked by about 21%

nervous system

abnormal nervous system physiology ( J:91092 )

• dihydropyridine (DHP) binding to cell membranes reduced to about 15%

abnormal CNS synaptic transmission ( J:91092 )

• BayK effect on dopamine and glutamate efflux attenuated in the ventral striatum