Phenotypes associated with this allele

• Allele Symbol: Igf1sl1^C3H/HeJ
• Allele Name: C3H/HeJ
• Allele ID: MGI:3046882
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ	B6.C3-(D6Mit93-D6Mit150)	MGI:3607510
hm2	Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ	involves: C3H/HeJ * C57BL/6J	MGI:3046889
ht3	Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3046890
cx4	Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J Igf1sl4^C3H/HeJ/Igf1sl4^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3046894
cx5	Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ Igf1sl4^C3H/HeJ/Igf1sl4^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3046892
cx6	Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ Igf1sl4^C57BL/6J/Igf1sl4^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3046891
cx7	Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J Igf1sl4^C57BL/6J/Igf1sl4^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3046893

Genotype
MGI:3607510

hm1

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ
• Genetic Background: B6.C3-(D6Mit93-D6Mit150)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:99471 , J:112375 )

• 20% decreased serum IGF-1 compared to C57BL/6J (J:99471)

• 13% decreased serum IGF-1 at 16 weeks of age in males (J:112375)

• 11%-21% decreased serum IGF-1 at 6, 8, and 16 weeks of age in females (J:112375)

skeleton

abnormal femur morphology ( J:112375 )

• decreased femoral bone volume fraction and bone thickness in females

short femur ( J:112375 )

• decreased femur length in females age 16 weeks

abnormal vertebral body morphology ( J:112375 )

• decreased vertebral body bone volume fraction and bone thickness in females

decreased bone mineral density ( J:99471 , J:112375 )

• decreased bone mineral density (J:99471)

• decreased total body area bone mineral density in females age 16 weeks (J:112375)

abnormal skeleton physiology ( J:99471 )

• 40% decreased IGF-1 expression in bone compared to C57BL/6J

liver/biliary system

abnormal hepatobiliary system physiology ( J:99471 )

• 40% decreased expression of IGF-1 and IGFBP-2 in liver compared to C57BL/6J

adipose tissue

decreased total body fat amount ( J:112375 )

• decreased body fat percentage in females age 12 weeks

increased percent body fat/body weight ( J:99471 )

limbs/digits/tail

abnormal femur morphology ( J:112375 )

• decreased femoral bone volume fraction and bone thickness in females

short femur ( J:112375 )

• decreased femur length in females age 16 weeks

Genotype
MGI:3046889

hm2

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 , J:94512 )

• decreased serum IGF-1 levels (J:94512)

skeleton

decreased bone mineral density of lumbar vertebrae ( J:94512 )

• reduced trabecular and cortical bone mineral density of the L5 vertebrae

decreased bone ossification ( J:94512 )

• reduced rate of bone formation

Genotype
MGI:3046890

ht3

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 )

• decreased serum IGF-1 levels

Genotype
MGI:3046894

cx4

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J; Igf1sl4^C3H/HeJ/Igf1sl4^C57BL/6J
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 )

• decreased serum IGF-1 levels

skeleton

decreased bone mineral density ( J:66640 )

Genotype
MGI:3046892

cx5

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ; Igf1sl4^C3H/HeJ/Igf1sl4^C57BL/6J
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 )

• decreased serum IGF-1 levels

skeleton

decreased bone mineral density ( J:66640 )

Genotype
MGI:3046891

cx6

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C3H/HeJ; Igf1sl4^C57BL/6J/Igf1sl4^C57BL/6J
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 )

• decreased serum IGF-1 levels

skeleton

decreased bone mineral density ( J:66640 )

Genotype
MGI:3046893

cx7

• Allelic Composition: Igf1sl1^C3H/HeJ/Igf1sl1^C57BL/6J; Igf1sl4^C57BL/6J/Igf1sl4^C57BL/6J
• Genetic Background: involves: C3H/HeJ * C57BL/6J

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:66640 )

• decreased serum IGF-1 levels

skeleton

decreased bone mineral density ( J:66640 )