Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Noda mutation
(0 available);
any
Mmp14 mutation
(43 available)
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normal phenotype
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• homozygous mutants are indistinguishable from wild-type littermates
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Noda mutation
(0 available);
any
Mmp14 mutation
(43 available)
Mmp2tm1Ito mutation
(1 available);
any
Mmp2 mutation
(25 available)
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growth/size/body
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• mutants weigh about 20% less than control littermates but are fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp14tm1Noda mutation
(0 available);
any
Mmp14 mutation
(43 available)
Mmp2tm1Ito mutation
(1 available);
any
Mmp2 mutation
(25 available)
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mortality/aging
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• neonates die within 10 minutes of birth
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cardiovascular system
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• the proportion of vessels with a diameter greater than 30 nm is reduced
• many capillaries with minimal luminal opening are seen
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growth/size/body
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• neonates weigh about 10 - 30% less than Mmp2tm1Ito single homozygotes
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homeostasis/metabolism
muscle
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• more muscle fibers appear to be immature with central nuclei present and in vitro myotube formation is impaired
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• the back and intercostal muscles have shorter muscle fibers in an abnormal wavy pattern
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• the diaphragm is consistently thinner in double mutants compared to Mmp2tm1Ito single homozygotes
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skeleton
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• the skull and bones are generally smaller
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• ossification and growth plate vascularization are impaired
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Analysis Tools
