Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-cre)43Smr
• Allele Name: transgene insertion 43, Sarah E Millar
• Allele ID: MGI:3046575
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esrp1^tm1.1Rpc/Esrp1^tm1.1Rpc Esrp2^tm1(KOMP)Vlcg/Esrp2^tm1(KOMP)Vlcg Tg(KRT14-cre)43Smr/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL/J	MGI:5707288
cn2	Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr Tg(KRT14-cre)43Smr/?	involves: 129S7/SvEvBrd * C57BL/6J * SJL/J	MGI:3046634

Genotype
MGI:5707288

cn1

• Allelic Composition: Esrp1^tm1.1Rpc/Esrp1^tm1.1Rpc; Esrp2^{tm1(KOMP)Vlcg}/Esrp2^{tm1(KOMP)Vlcg}; Tg(KRT14-cre)43Smr/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL/J
• Cell Lines: 13762A-G3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:226997 )

• neonates are viable at birth (P0.5) however pups do not survive to the following day (P1.5)

integument

impaired skin barrier function ( J:226997 )

• in a water loss assay, mutant pups lose more weight compared to controls, indicating a skin barrier defect

dry skin ( J:226997 )

shiny skin ( J:226997 )

• red shiny skin

homeostasis/metabolism

impaired skin barrier function ( J:226997 )

• in a water loss assay, mutant pups lose more weight compared to controls, indicating a skin barrier defect

Genotype
MGI:3046634

cn2

• Allelic Composition: Bmpr1a^tm2Bhr/Bmpr1a^tm2Bhr; Tg(KRT14-cre)43Smr/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J

skeleton

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

mortality/aging

neonatal lethality, complete penetrance ( J:91054 )

• died within 24 hours

behavior/neurological

abnormal suckling behavior ( J:91054 )

• difficulty suckling

craniofacial

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars

limbs/digits/tail

absent hindlimb ( J:91054 )

vision/eye

eyelids open at birth ( J:91054 )

integument

increased hair follicle number ( J:91054 )

• dorsal follicle density significantly increased

growth/size/body

abnormal mouth morphology ( J:91054 )

• oral abnormalities resulting from defective tooth development

abnormal tooth development ( J:91054 )

• dental lamina at E13.5 and tooth bud formation is initiated but small and poorly developed

• regression of tooth buds by E16.5

absent teeth ( J:91054 )

• complete absence of incisors and molars