Phenotypes associated with this allele

• Allele Symbol: Fabp2^tm1Mto
• Allele Name: targeted mutation 1, Matthew J Toth
• Allele ID: MGI:3046293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fabp2^tm1Mto/Fabp2^tm1Mto	B6.129S1-Fabp2^tm1Mto	MGI:3046295

Genotype
MGI:3046295

hm1

• Allelic Composition: Fabp2^tm1Mto/Fabp2^tm1Mto
• Genetic Background: B6.129S1-Fabp2^tm1Mto

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:64975 )

• females on a high fat diet gain less weight (70%) than controls by 25 weeks of age

increased susceptibility to diet-induced obesity ( J:64975 )

• weight gain about 110% over controls in males but not in females on a low fat diet

• 130% increase in weight by 25 weeks of age on a high fat diet in males

increased circulating insulin level ( J:64975 )

• in both sexes but plasma glucose remains normal

increased circulating leptin level ( J:64975 )

• plasma levels elevated in males but not in females

abnormal circulating lipid level ( J:64975 )

decreased circulating cholesterol level ( J:64975 )

• females with lower plasma cholesterol levels than controls when on a high fat diet

increased circulating glycerol level ( J:64975 )

• increased plasma triacylglycerol in males

adipose tissue

increased epididymal fat pad weight ( J:64975 )

• males on a low fat diet with epididymal fat pad mass about 200% that of controls

decreased uterine fat pad weight ( J:64975 )

• females on a high fat diet with uterine fat pad weights about 65% that of controls

liver/biliary system

increased liver weight ( J:64975 )

• liver weight of males on a high fat diet increased 200% over controls

decreased liver weight ( J:64975 )

• female liver mass about 93% of controls on a high fat diet

renal/urinary system

increased kidney weight ( J:64975 )

• male kidney mass about 120% that of controls regardless of diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:64975 )

• females on a high fat diet gain less weight (70%) than controls by 25 weeks of age

increased susceptibility to diet-induced obesity ( J:64975 )

• weight gain about 110% over controls in males but not in females on a low fat diet

• 130% increase in weight by 25 weeks of age on a high fat diet in males

increased kidney weight ( J:64975 )

• male kidney mass about 120% that of controls regardless of diet

increased liver weight ( J:64975 )

• liver weight of males on a high fat diet increased 200% over controls