Phenotypes associated with this allele

• Allele Symbol: Mmp9^tm1Arnd
• Allele Name: targeted mutation 1, Bernd Arnold
• Allele ID: MGI:3046278
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp9^tm1Arnd/Mmp9^tm1Arnd	B6.129P2-Mmp9^tm1Arnd	MGI:3652525
hm2	Mmp9^tm1Arnd/Mmp9^tm1Arnd	involves: 129P2/OlaHsd	MGI:3046282

Genotype
MGI:3652525

hm1

• Allelic Composition: Mmp9^tm1Arnd/Mmp9^tm1Arnd
• Genetic Background: B6.129P2-Mmp9^tm1Arnd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased vascular permeability ( J:110450 )

• induction of peritonitis by zymosan injection results in increased vasopermeability compared to induced controls; removal of peritoneal macrophages, but not mast cells, from mutants reduces the zymosan-induced vasopermeability

homeostasis/metabolism

decreased histamine level ( J:110450 )

• homozygotes with induced peritonitis exhibit significantly lower histamine content in the peritoneal exudate

increased prostaglandin level ( J:110450 )

• homozygotes with induced peritonitis exhibit significantly higher levels of PGE2 in the peritoneal exudate

Genotype
MGI:3046282

hm2

• Allelic Composition: Mmp9^tm1Arnd/Mmp9^tm1Arnd
• Genetic Background: involves: 129P2/OlaHsd

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:58833 )

• mutant mice exhibit a decreased susceptibility to experimental autoimmune encephalitis (EAE) at 4 weeks of age

• adult mice could develop symptoms of EAE, but both young and adult mutant mice were resistant to necrotizing tail lesions that are present in controls

reproductive system

reduced fertility ( J:64545 )

• the number of mice born per breeding pair over a three month period is smaller; the percentage of infertile breeding pairs is elevated

decreased litter size ( J:64545 )

• litter sizes are smaller compared to controls