All Phenotypes Rspo2<ftls> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rspo2^ftls
footless
MGI:3045965

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rspo2^ftls/Rspo2^ftls	involves: FVB/N	MGI:3045978
hm2	Rspo2^ftls/Rspo2^ftls	Not Specified	MGI:5512637
ht3	Rspo2^ftls/Rspo2⁺	involves: FVB/N	MGI:3045981
cn4	Rspo2^ftls/Rspo2^ftls Rspo3^tm1.1Jcob/Rspo3^tm1.2Jcob Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL	MGI:5443990

Allelic Composition	Rspo2^ftls/Rspo2^ftls
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2^ftls mutation (0 available); any Rspo2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:83881 )

• at c-section at E18, mice exhibit a gasping reflex but fail to breath and die within hours

craniofacial

cleft secondary palate ( J:83881 )

• observed in 100%

limbs/digits/tail

abnormal phalanx morphology ( J:83881 )

• loss of all or most of the distal phalanx on all formed digits

abnormal forelimb morphology ( J:83881 )

• anterior structures are missing from the right forelimb, whereas the left forelimb is typically intact

• ~50% of right forelimbs are missing anterior structures including digits 1, 2, and 3 and the radius

• 1 of 77 left forelimbs showed an absence of a skeletal element

absent radius ( J:83881 )

abnormal hindlimb morphology ( J:83881 )

• posterior structures from the autopod and zeugopod are missing with increased frequency and severity in the left hindlimb relative to the right hindlimb

absent fibula ( J:83881 )

• in some mice and sometimes accompanied by a shortening of the tibia

short tibia ( J:83881 )

• in some mice

renal/urinary system

abnormal kidney development ( J:83881 )

• bilateral supernumerary kidneys observed in some fetuses

single kidney ( J:83881 )

• unilateral absence in some fetuses

skeleton

abnormal phalanx morphology ( J:83881 )

• loss of all or most of the distal phalanx on all formed digits

absent radius ( J:83881 )

absent fibula ( J:83881 )

• in some mice and sometimes accompanied by a shortening of the tibia

short tibia ( J:83881 )

• in some mice

digestive/alimentary system

cleft secondary palate ( J:83881 )

• observed in 100%

integument

absence of all nails ( J:83881 )

• nails were absent from all formed digits

growth/size/body

cleft secondary palate ( J:83881 )

• observed in 100%

Allelic Composition	Rspo2^ftls/Rspo2^ftls
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2^ftls mutation (0 available); any Rspo2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rspo2^ftls/Rspo2^ftls Rspo3^tm1.1Jcob/Rspo3^tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

limbs/digits/tail

abnormal limb morphology ( J:188812 )

• variable limb defects, with the most severe mutants having a missing autopod, fibula and distal tibia

abnormal autopod morphology ( J:188812 )

• 26% of mice have a missing left autopod and an intact right autopod

abnormal autopod rotation ( J:188812 )

• 63% of mice exhibit malformed autopods

abnormal digit morphology ( J:188812 )

• 63% of mice have substantial autopod elements on both hindlimbs, although usually with missing/malformed digits

• in forelimbs, commonly one or two anterior digits are absent

abnormal forelimb morphology ( J:188812 )

• in forelimbs, the radius is sometimes missing, but more commonly one or two anterior digits are absent

absent radius ( J:188812 )

• in forelimbs, the radius is sometimes missing

abnormal hindlimb morphology ( J:188812 )

• left hindlimb is usually most severely affected

absent fibula ( J:188812 )

• in most severely affected mutants

absent tibia ( J:188812 )

• in most severely affected mutants

short hindlimb ( J:188812 )

• 2 of 19 mutants have severe truncations in both hindlimbs

skeleton

absent radius ( J:188812 )

• in forelimbs, the radius is sometimes missing

absent fibula ( J:188812 )

• in most severely affected mutants

absent tibia ( J:188812 )

• in most severely affected mutants

Allelic Composition	Rspo2^ftls/Rspo2⁺
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2^ftls mutation (0 available); any Rspo2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

endocrine/exocrine glands

ovary cyst ( J:83881 )

• observed in some females

renal/urinary system

delayed kidney development ( J:83881 )

• bilateral supernumerary kidneys observed in some fetuses

single kidney ( J:83881 )

• unilateral absence in some fetuses

reproductive system

ovary cyst ( J:83881 )

• observed in some females

decreased ovulation rate ( J:83881 )

• decreased ovulation rates, possibly due to diminished hormonal responsiveness or ovarian cysts

reduced female fertility ( J:83881 )

• females were found to be fertile until ~4 months of age

digestive/alimentary system

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

growth/size/body

cleft secondary palate ( J:83881 )

• observed in 2 of 125 fetuses

ovary cyst ( J:83881 )

• observed in some females

Allelic Composition	Rspo2^ftls/Rspo2^ftls Rspo3^tm1.1Jcob/Rspo3^tm1.2Jcob Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2^ftls mutation (0 available); any Rspo2 mutation (19 available)
Rspo3^tm1.1Jcob mutation (1 available); any Rspo3 mutation (14 available)
Rspo3^tm1.2Jcob mutation (0 available); any Rspo3 mutation (14 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rspo2^ftls/Rspo2^ftls Rspo3^tm1.1Jcob/Rspo3^tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

mortality/aging

neonatal lethality, complete penetrance ( J:188812 )

• mice die at birth as do Rspo2^ftls homozygotes

limbs/digits/tail

abnormal digit morphology ( J:188812 )

• in the forelimb

adactyly ( J:188812 )

• in digits of the forelimbs in 5 of 6 mice; all mice lack 1 digit

brachydactyly ( J:188812 )

• three shortened middle digits

abnormal forelimb morphology ( J:188812 )

• more subtle than in hindlimbs

abnormal humerus morphology ( J:188812 )

abnormal hindlimb morphology ( J:188812 )

• at birth, mice lack most of their hindlimbs

• hindlimb abnormalities are more severe more proximally than in Rspo2^ftls homozygotes

bowed femur ( J:188812 )

• severely shortened and bent in two mice

short femur ( J:188812 )

• severely shortened in two mice

absent tibia ( J:188812 )

• in one mouse

short tibia ( J:188812 )

respiratory system

abnormal lung morphology ( J:188812 )

• as in Rspo2^ftls homozygotes

behavior/neurological

absent gastric milk in neonates ( J:188812 )

• as in Rspo2^ftls homozygotes

skeleton

abnormal humerus morphology ( J:188812 )

bowed femur ( J:188812 )

• severely shortened and bent in two mice

short femur ( J:188812 )

• severely shortened in two mice

absent tibia ( J:188812 )

• in one mouse

short tibia ( J:188812 )

abnormal scapula morphology ( J:188812 )

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