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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrf2tm1Feig
targeted mutation 1, Larry A Feig
MGI:3045891
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rasgrf1tm1Sva/Rasgrf1tm1Sva
Rasgrf2tm1Feig/Rasgrf2tm1Feig 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3046171


Genotype
MGI:3046171
cx1
Allelic
Composition		 Rasgrf1tm1Sva/Rasgrf1tm1Sva
Rasgrf2tm1Feig/Rasgrf2tm1Feig
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm1Sva mutation (0 available); any Rasgrf1 mutation (65 available)
Rasgrf2tm1Feig mutation (0 available); any Rasgrf2 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to ischemic brain injury ( J:90111 )
• stroke induced by occlusion of the right middle cerebral artery resulted in about 2 fold larger lesions in double homozygous mice
• no or only slight increases in the size of lesions is seen in either single homozygote

homeostasis/metabolism
increased susceptibility to ischemic brain injury ( J:90111 )
• stroke induced by occlusion of the right middle cerebral artery resulted in about 2 fold larger lesions in double homozygous mice
• no or only slight increases in the size of lesions is seen in either single homozygote




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory