All Phenotypes Nkx3-1<tm1.1Saa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx3-1^tm1.1Saa
targeted mutation 1.1, Sarki A Abdulkadir
MGI:3045877

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx3-1^tm1.1Saa/Nkx3-1^tm1.1Saa	involves: C57BL/6	MGI:3046059
cx2	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Nkx3-1^tm1.1Saa/Nkx3-1^tm1.1Saa	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3046061

Allelic Composition	Nkx3-1^tm1.1Saa/Nkx3-1^tm1.1Saa
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1^tm1.1Saa mutation (0 available); any Nkx3-1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

preneoplasia ( J:74350 , J:89571 )

• hyperplasia and dysplasia in the prostate (J:74350)

• lesions did not progress to invasive carcinomas for up to 1 year (J:74350)

• lesions were more extensive in the anterior lobe of the prostate (J:89571)

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Nkx3-1^tm1.1Saa/Nkx3-1^tm1.1Saa
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (25 available)
Nkx3-1^tm1.1Saa mutation (0 available); any Nkx3-1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:89571 )

• incidence of prostatic intraepithelial neoplasia was 100% by 24 weeks of age

preneoplasia ( J:89571 )

• extensive lesions in the prostate

• nuclear crowding and elongation as well as hyperchromasia

• increased proliferation of prostatic epithelial cells

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:89571 )

• incidence of prostatic intraepithelial neoplasia was 100% by 24 weeks of age

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:89571 )

• incidence of prostatic intraepithelial neoplasia was 100% by 24 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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