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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2Cog
targeted mutation 2, Michel Cogne
MGI:3045811
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2Cog/Ightm2Cog involves: 129S2/SvPas * C57BL/6 MGI:3045892
ht2
 		Ightm2Cog/Igh+ involves: 129S2/SvPas * C57BL/6 MGI:3045894


Genotype
MGI:3045892
hm1
Allelic
Composition		 Ightm2Cog/Ightm2Cog
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cog mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased pre-B cell number ( J:90548 )
• a 2-3 fold increase in pre-B cell numbers is seen
decreased IgG level ( J:90548 )
• a 2-5 fold decrease in IgG3 and IgG2b titers and a 2-10 fold decrease in IgG1 and IgG2a are seen
• stimulation of splenocytes with lipopolysaccharide revealed a 10-100 fold reduction in IgG3, IgG2b, and IgG1 production

immune system
increased pre-B cell number ( J:90548 )
• a 2-3 fold increase in pre-B cell numbers is seen
decreased IgG level ( J:90548 )
• a 2-5 fold decrease in IgG3 and IgG2b titers and a 2-10 fold decrease in IgG1 and IgG2a are seen
• stimulation of splenocytes with lipopolysaccharide revealed a 10-100 fold reduction in IgG3, IgG2b, and IgG1 production




Genotype
MGI:3045894
ht2
Allelic
Composition		 Ightm2Cog/Igh+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cog mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:90548 )
• stimulation of splenocytes with lipopolysaccharide revealed a 50% reduction in IgG3, IgG2b, and IgG1 production

hematopoietic system
decreased IgG level ( J:90548 )
• stimulation of splenocytes with lipopolysaccharide revealed a 50% reduction in IgG3, IgG2b, and IgG1 production




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory