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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rfx3tm2Wrth
targeted mutation 2, W Reith
MGI:3045793
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rfx3tm2Wrth/Rfx3tm2Wrth involves: 129 * C57BL/6J MGI:3045870
cn2
 		Gfi1tm1(cre)Gan/Gfi1+
Rfx3tm2Wrth/Rfx3tm2Wrth 		involves: 129 * 129S7/SvEvBrd MGI:5907529
cn3
 		Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth
Rfx3tm2Wrth/Rfx3tm2Wrth 		involves: 129 * 129S7/SvEvBrd MGI:5907531


Genotype
MGI:3045870
hm1
Allelic
Composition		 Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfx3tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:89880 )
• homozygous mutants have no obvious phenotype




Genotype
MGI:5907529
cn2
Allelic
Composition		 Gfi1tm1(cre)Gan/Gfi1+
Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic
Background		 involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx3tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:227631 )
N
• normal hearing thresholds at 3 months of age




Genotype
MGI:5907531
cn3
Allelic
Composition		 Gfi1tm1(cre)Gan/Gfi1+
Rfx1tm1.1Wrth/Rfx1tm1.1Wrth
Rfx3tm2Wrth/Rfx3tm2Wrth
Genetic
Background		 involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Rfx1tm1.1Wrth mutation (0 available); any Rfx1 mutation (46 available)
Rfx3tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
decreased cochlear outer hair cell number ( J:227631 )
• widespread loss of outer hair cells by P15
cochlear inner hair cell degeneration ( J:227631 )
• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
abnormal cochlear outer hair cell physiology ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15
impaired hearing ( J:227631 )
• rapid progressive hearing loss beginning at P22 with no measurable hearing by 3 months of age
deafness ( J:227631 )
• no measurable hearing by 3 months of age

nervous system
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
decreased cochlear outer hair cell number ( J:227631 )
• widespread loss of outer hair cells by P15
cochlear inner hair cell degeneration ( J:227631 )
• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
abnormal cochlear outer hair cell physiology ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

cellular
abnormal inner hair cell kinocilium morphology ( J:227631 )
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
increased apoptosis ( J:227631 )
• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory