Phenotypes associated with this allele

• Allele Symbol: Tg(APOE-Artn)1Wss
• Allele Name: transgene insertion 1, W Scott Simonet
• Allele ID: MGI:3045598
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(APOE-Artn)1Wss/0	involves: C57BL/6Crl * DBA/2Crl	MGI:3045602

Genotype
MGI:3045602

tg1

• Allelic Composition: Tg(APOE-Artn)1Wss/0
• Genetic Background: involves: C57BL/6Crl * DBA/2Crl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased adrenal gland tumor incidence ( J:90843 )

• aged transgenic mice develop complex pheochromocytomas or neuroblastomas in the adrenal medulla

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:90843 )

• in mild cases the caudal pole of the adrenal gland is broached and the distribution of cells into distinct cortical and medullary regions is disrupted

• in severe cases, the adrenal medulla and much of the cortex are replaced by proliferating neurons

abnormal adrenal medulla morphology ( J:90843 )

• dysgenesis and fusion of cells in the adrenal medulla are seen

increased adrenal gland tumor incidence ( J:90843 )

• aged transgenic mice develop complex pheochromocytomas or neuroblastomas in the adrenal medulla

nervous system

abnormal autonomic nervous system morphology ( J:90843 )

• hyperplasia of the autonomic ganglia and nerves in the pelvic connective tissue is seen

abnormal enteric nervous system morphology ( J:90843 )

• the size and number of the myenteric ganglia and their constituent parasympathetic neurons is increased in the colon

abnormal parasympathetic ganglion morphology ( J:90843 )

• cells in the paraganglion adjacent to the adrenal gland are fused and dysgenic

• in severe cases where much of the adrenal gland is replaced by proliferating neurons the adjacent paraganglia are enlarged