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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ank+
wild type
MGI:3045422
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Anktm1.1Ejr/Ank+ B6.129-Anktm1.1Ejr MGI:4889221
cn2
 		Anktm1Kng/Ank+
Tg(Gdf5-cre,-ALPP)1Kng/? 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3715341


Genotype
MGI:4889221
ht1
Allelic
Composition		 Anktm1.1Ejr/Ank+
Genetic
Background		 B6.129-Anktm1.1Ejr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anktm1.1Ejr mutation (0 available); any Ank mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:168526 )
• significantly reduced osteoclast formation
abnormal craniofacial bone morphology ( J:168526 )
• highly variable hyperosteosis of cranial bones at 1 year of age
abnormal femur morphology ( J:168526 )
• extensive trabeculae in the diaphysis at 1 year of age
club-shaped femur ( J:168526 )
• club shaped femurs at 1 year of age

limbs/digits/tail
abnormal femur morphology ( J:168526 )
• extensive trabeculae in the diaphysis at 1 year of age
club-shaped femur ( J:168526 )
• club shaped femurs at 1 year of age

craniofacial
abnormal craniofacial bone morphology ( J:168526 )
• highly variable hyperosteosis of cranial bones at 1 year of age

hematopoietic system
abnormal osteoclast differentiation ( J:168526 )
• significantly reduced osteoclast formation

immune system
abnormal osteoclast differentiation ( J:168526 )
• significantly reduced osteoclast formation

cellular
abnormal osteoclast differentiation ( J:168526 )
• significantly reduced osteoclast formation




Genotype
MGI:3715341
cn2
Allelic
Composition		 Anktm1Kng/Ank+
Tg(Gdf5-cre,-ALPP)1Kng/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anktm1Kng mutation (1 available); any Ank mutation (33 available)
Tg(Gdf5-cre,-ALPP)1Kng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cementum morphology ( J:122727 )
• expanded layer of cementum
abnormal joint morphology ( J:122727 )
• 64 of 84 mutants have abnormal joints
• ectopic cartilage depositions occurs similar to in Anktm1.1Kng homozygotes
• ectopic mineral deposition in joints
abnormal articular cartilage morphology ( J:122727 )
• articular cartilage of joints is disrupted
fused joints ( J:122727 )
• ankylosis, however joint fusion is delayed compared to Ankank or Anktm1.1Kng homozygotes
decreased joint mobility ( J:122727 )
• at 9 weeks, mice develop decreased mobility in the distal joints

craniofacial
abnormal cementum morphology ( J:122727 )
• expanded layer of cementum

growth/size/body
abnormal cementum morphology ( J:122727 )
• expanded layer of cementum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory