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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp1btm1Her
targeted mutation 1, Joachim Herz
MGI:3045402
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp1btm1Her/Lrp1btm1Her 129S/SvEv-Lrp1btm1Her MGI:3045502
hm2
 		Lrp1btm1Her/Lrp1btm1Her involves: 129S/SvEv * C57BL/6 MGI:3045501
cx3
 		Lrp1btm1Her/Lrp1btm1Her
Lrpap1tm1Her/Lrpap1tm1Her 		involves: 129S/SvEv * C57BL/6 MGI:3045503


Genotype
MGI:3045502
hm1
Allelic
Composition		 Lrp1btm1Her/Lrp1btm1Her
Genetic
Background		 129S/SvEv-Lrp1btm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Her mutation (0 available); any Lrp1b mutation (303 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:90197 )
• homozygous mutants do not display any obvious abnormalities




Genotype
MGI:3045501
hm2
Allelic
Composition		 Lrp1btm1Her/Lrp1btm1Her
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Her mutation (0 available); any Lrp1b mutation (303 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:90197 )
• homozygous mutants appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors




Genotype
MGI:3045503
cx3
Allelic
Composition		 Lrp1btm1Her/Lrp1btm1Her
Lrpap1tm1Her/Lrpap1tm1Her
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Her mutation (0 available); any Lrp1b mutation (303 available)
Lrpap1tm1Her mutation (3 available); any Lrpap1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:90197 )
• homozygous mutants appear normal and have normal brain physiology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory