digestive/alimentary system
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• the zymogenic cells of the glandular stomach are severely decreased
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• increase in parietal cells
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reproductive system
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• 60% of E7.5 mutants have low counts of primordial germ cells while some E13.5 embryos, both males and females, lack primordial germ cells
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• 2/7 of males have abnormal reproductive tracts
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• testis cords of affected males are disorganized and depleted of primordial germ cells
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• 2/7 of males have small testes
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• intercrosses between homozygous mutants are less productive than those between heterozygotes
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cellular
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• embryonic fibroblasts display stronger intercellular contacts, an accumulation of cortical actin and a decrease in stress fibers compared to wild-type MEFs
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• 60% of E7.5 mutants have low counts of primordial germ cells while some E13.5 embryos, both males and females, lack primordial germ cells
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endocrine/exocrine glands
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• the zymogenic cells of the glandular stomach are severely decreased
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• increase in parietal cells
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• testis cords of affected males are disorganized and depleted of primordial germ cells
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• 2/7 of males have small testes
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