Phenotypes associated with this allele

• Allele Symbol: Sls
• Allele Name: semidominant lethal spotting
• Allele ID: MGI:3045164
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sls/Sls	C57BL/6J-Sls/GrsrJ	MGI:3051412
ht2	Sls/Sls^+	C57BL/6J-Sls/GrsrJ	MGI:3051415

Genotype
MGI:3051412

hm1

• Allelic Composition: Sls/Sls
• Genetic Background: C57BL/6J-Sls/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sls/Sls

mortality/aging

premature death ( J:91387 )

• some homozygotes die prematurely due to megacolon

pigmentation

white spotting ( J:91387 )

• homozygous mutants exhibit large areas of white spotting by weaning age

digestive/alimentary system

megacolon ( J:91387 )

• observed in some homozygotes; incompletely penetrant; lethal when present

integument

white spotting ( J:91387 )

• homozygous mutants exhibit large areas of white spotting by weaning age

Genotype
MGI:3051415

ht2

• Allelic Composition: Sls/Sls⁺
• Genetic Background: C57BL/6J-Sls/GrsrJ

pigmentation

white spotting ( J:91387 )

• heterozygotes have small white spots on the belly

renal/urinary system

hydronephrosis ( J:91387 )

• observed upon pathological examination of some mutants; incompletely penetrant

nervous system

hydrocephaly ( J:91387 )

• observed upon pathological examination of some mutants; incompletely penetrant

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:91387 )

N • mutant mice have normal hearing as determined by acoustic brainstem response (ABR)

vision/eye

vision/eye phenotype ( J:91387 )

N • eyes appear normal by ophthalmoscopic examination

integument

white spotting ( J:91387 )

• heterozygotes have small white spots on the belly