Phenotypes associated with this allele

• Allele Symbol: Prlhr^tm1Askr
• Allele Name: targeted mutation 1, Alain Stricker-Krongrad
• Allele ID: MGI:3044896
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prlhr^tm1Askr/Prlhr^tm1Askr	involves: 129S5/SvEvBrd * C57BL/6	MGI:3045499

Genotype
MGI:3045499

hm1

• Allelic Composition: Prlhr^tm1Askr/Prlhr^tm1Askr
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food preference ( J:90533 )

• ate 22% more than controls on a regular diet but about the same amount as controls on a high fat diet

growth/size/body

increased susceptibility to weight gain ( J:90533 )

• although weight was normal when young, weights were significantly increased at 16 weeks in males and 26 weeks of age in females

• weight gain on a regular diet was similar to controls on a high fat diet

• due primarily to increased body fat and correlated to a 4X increase in circulating leptin

homeostasis/metabolism

increased circulating insulin level ( J:90533 )

• increased 3 fold over controls on a normal diet

insulin resistance ( J:90533 )

• were insulin resistant in a glucose tolerance test