Analysis Tools
mortality/aging
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• slightly fewer than expected mice are present at birth
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Allele Symbol Allele Name Allele ID |
Twsg1tm1Emdr targeted mutation 1, E M De Robertis MGI:3044357 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly fewer than expected mice are present at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• weight was 10-20% less than normal littermates
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• caudal vertebrae shorter than normal and bone is less dense
• 2 centers of ossification in tail vertebrae and asymmetrical growth leads to kinks
• by E15.5, vertebral bodies of tail were narrower and more rectangular, fewer differentiated chondrocytes
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• 80% of homozygotes with multiple kinks
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• caudal vertebrae shorter than normal and bone is less dense
• 2 centers of ossification in tail vertebrae and asymmetrical growth leads to kinks
• by E15.5, vertebral bodies of tail were narrower and more rectangular, fewer differentiated chondrocytes
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• abnormal development and increased intervertebral tissue
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• defective development, often fail to close
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• notochordal cells are not resorbed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• more mice than expected are born and mice do not die at birth unlike Bmpertm1Emdr homozygotes
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| N |
• mice exhibit normal tracheal rings, humerus morphology, skull, neural arches and number of ribs
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• mice lack spinal column ossification centers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly fewer than expected mice are present at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe head malformations with 64% penetrance
• phenotype similar in newborns and at E15.5
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• single nostril
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• low "implantation" of external ears
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• low "implantation" of external ears
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• caudal vertebrae shorter than normal and bone is less dense
• 2 centers of ossification in tail vertebrae and asymmetrical growth leads to kinks
• by E15.5, vertebral bodies of tail were narrower and more rectangular, fewer differentiated chondrocytes
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• 80% of homozygotes with multiple kinks
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• single nostril
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• caudal vertebrae shorter than normal and bone is less dense
• 2 centers of ossification in tail vertebrae and asymmetrical growth leads to kinks
• by E15.5, vertebral bodies of tail were narrower and more rectangular, fewer differentiated chondrocytes
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• lens did not develop
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• retina did not develop
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• single cavity, lack of ventricle medial wall (holoprosencephaly)
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• malformed prosencephalon
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• thickened basal diencephalons at the level of the hypothalamus
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• lateral ganglionic eminence is missing
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• single nostril
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• low "implantation" of external ears
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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