All Phenotypes Tnfsf4<Ath1-C57BL/6J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfsf4^{Ath1-C57BL/6J}
C57BL/6J
MGI:3044290

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-C57BL/6J}	B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn	MGI:3576511
cx2	Tnfsf4^{Ath1-C57BL/6J}/Tnfsf4^{Ath1-C57BL/6J} Ath2^C57BL/6J/Ath2^C57BL/6J	involves: C3H/HeJ * C57BL/6J	MGI:3044377
cx3	Apoe^tm1Unc/Apoe^tm1Unc Tnfsf4^{Ath1-C57BL/6J}/Tnfsf4^{Ath1-C57BL/6J}	involves: C3H/HeJ * C57BL/6J	MGI:3819480
ot4	Tnfsf4^{Ath1-C57BL/6J}/?	involves: BALB/cJ * C57BL/6J	MGI:3044364
ot5	Tnfsf4^{Ath1-C57BL/6J}/?	involves: C3H/HeJ * C57BL/6J	MGI:3044365

Allelic Composition	Tnfsf4^{Ath1-PERA/EiJ}/Tnfsf4^{Ath1-C57BL/6J}
Genetic Background	B6.PERA-Tnfsf4^{Ath1-PERA/EiJ}/Pgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4^{Ath1-C57BL/6J} mutation (0 available); any Tnfsf4 mutation (31 available)
Tnfsf4^{Ath1-PERA/EiJ} mutation (1 available); any Tnfsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:79722 )

• mice heterozygous for the PERA/EiJ allele exhibit higher HDL cholesterol levels than do those homozygous for the C57BL/6J allele

Allelic Composition	Tnfsf4^{Ath1-C57BL/6J}/Tnfsf4^{Ath1-C57BL/6J} Ath2^C57BL/6J/Ath2^C57BL/6J
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ath2^C57BL/6J mutation (0 available); any Ath2 mutation (0 available)
Tnfsf4^{Ath1-C57BL/6J} mutation (0 available); any Tnfsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:9832 )

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:9832 )

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Tnfsf4^{Ath1-C57BL/6J}/Tnfsf4^{Ath1-C57BL/6J}
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (146 available)
Tnfsf4^{Ath1-C57BL/6J} mutation (0 available); any Tnfsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:140288 )

• increased aortic lesion area in female animals fed a high fat diet

Allelic Composition	Tnfsf4^{Ath1-C57BL/6J}/?
Genetic Background	involves: BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4^{Ath1-C57BL/6J} mutation (0 available); any Tnfsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiovascular system morphology ( J:8735 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:8735 )

Allelic Composition	Tnfsf4^{Ath1-C57BL/6J}/?
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4^{Ath1-C57BL/6J} mutation (0 available); any Tnfsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:8735 )

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:8735 , J:9135 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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