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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-HIST1H2BJ/GFP)47Efu
transgene insertion 47, Elaine Fuchs
MGI:3044190
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:5581950
cx2
 		S1pr1tm3.1(tTA,-Arrb2)Rlp/S1pr1+
Tg(tetO-HIST1H2BJ/GFP)47Efu/0 		involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N MGI:5588125
cx3
 		Tg(tetO-HIST1H2BJ/GFP)47Efu/?
Waptm2(rtTA)Kuw/Wap+ 		involves: 129X1/SvJ * CD-1 MGI:3846834


Genotype
MGI:5581950
cn1
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ppargtm1.1(tTA)Jmgr/Pparg+
Tg(tetO-cre)1Jaw/0
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (51 available)
Ppargtm1.1(tTA)Jmgr mutation (1 available); any Pparg mutation (42 available)
Tg(tetO-cre)1Jaw mutation (7 available)
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

hematopoietic system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

cellular
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice

immune system
abnormal osteoclast differentiation ( J:178340 )
• cultured bone marrow cells contain fewer osteoclast precursors compared with control mice




Genotype
MGI:5588125
cx2
Allelic
Composition		 S1pr1tm3.1(tTA,-Arrb2)Rlp/S1pr1+
Tg(tetO-HIST1H2BJ/GFP)47Efu/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1tm3.1(tTA,-Arrb2)Rlp mutation (1 available); any S1pr1 mutation (29 available)
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:212772 )
N
• mice are born in the expected Mendelian ratio

immune system
immune system phenotype ( J:212772 )
N
• mice exhibit normal numbers of B cells, CD4+ T cells, CD8+ T cells and monocytes




Genotype
MGI:3846834
cx3
Allelic
Composition		 Tg(tetO-HIST1H2BJ/GFP)47Efu/?
Waptm2(rtTA)Kuw/Wap+
Genetic
Background		 involves: 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO-HIST1H2BJ/GFP)47Efu mutation (2 available)
Waptm2(rtTA)Kuw mutation (1 available); any Wap mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:148684 )
• knock-in allele expression determined by use of this strain




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory