Phenotypes associated with this allele

• Allele Symbol: Tmod1^tm1Sung
• Allele Name: targeted mutation 1, Lanping Amy Sung
• Allele ID: MGI:3043840
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmod1^tm1Sung/Tmod1^tm1Sung	involves: 129S1/Sv * 129X1/SvJ	MGI:3043845

Genotype
MGI:3043845

hm1

• Allelic Composition: Tmod1^tm1Sung/Tmod1^tm1Sung
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89956 )

• homozygous embryos die around E10 from heart failure

cardiovascular system

abnormal vascular development ( J:89956 )

• vascular chambers appear to be decreased in the embryo proper

abnormal vitelline vasculature morphology ( J:89956 )

• the primitive vascular plexus fails to develop into a mature vascular network in homozygous embryos

• at E9.0 the vascular plexuses fuse to form large blood pockets

abnormal myocardial fiber morphology ( J:89956 )

• myofibril bundles formed elongated stress fiberlike dense bodies or highly disorganized arrays with little interdigitation of thin and thick fibers rather than the organized M and Z lines seen in wild-type hearts

abnormal myocardial trabeculae morphology ( J:89956 )

• at E9.5 the single fused chamber has overdeveloped trabeculae

• trabecular myocytes are increased in number and more discontinuous in homozygous embryos

abnormal heart looping ( J:89956 )

• between E9.0 and E10.5 homozygous embryos display abnormal looping

abnormal heart tube morphology ( J:89956 )

• at E9.5 the heart tube consists of only a single fused chamber

• the right ventricle fails to develop in hearts from homozygous mutants

• the single ventricle is abruptly connected to the outflow tract

pericardial effusion ( J:89956 )

• at E9.5 massive pericardial effusion can be seen in homozygous embryos

irregular heartbeat ( J:89956 )

• at E9.5 the developing heart in homozygous embryos produces only minor tremors instead of the peristaltic contractions seen in hearts from wild-type mice

embryo

abnormal vitelline vasculature morphology ( J:89956 )

• the primitive vascular plexus fails to develop into a mature vascular network in homozygous embryos

• at E9.0 the vascular plexuses fuse to form large blood pockets

embryonic growth retardation ( J:89956 )

• significant growth retardation is seen by E9.5 in homozygous embryos

abnormal embryonic tissue morphology ( J:89956 )

• at E9.5 decreased growth of the brain and facial primordia is seen in homozygous embryos

hematopoietic system

anemia ( J:89956 )

• anemia is seen in the embryo proper however blood is present in the yolk sac

abnormal erythrocyte morphology ( J:89956 )

• erythroid cell membranes from homozygous embryos fragment and deform more easily compared to erythroid cells from wild-type embryos

abnormal embryonic erythrocyte morphology ( J:89956 )

• about 2% of primitive red blood cells are binucleated in homozygous embryos, no binucleated red blood cells are seen in wild-type embryos

muscle

abnormal myocardial fiber morphology ( J:89956 )

• myofibril bundles formed elongated stress fiberlike dense bodies or highly disorganized arrays with little interdigitation of thin and thick fibers rather than the organized M and Z lines seen in wild-type hearts

abnormal myocardial trabeculae morphology ( J:89956 )

• at E9.5 the single fused chamber has overdeveloped trabeculae

• trabecular myocytes are increased in number and more discontinuous in homozygous embryos

growth/size/body

embryonic growth retardation ( J:89956 )

• significant growth retardation is seen by E9.5 in homozygous embryos

homeostasis/metabolism

pericardial effusion ( J:89956 )

• at E9.5 massive pericardial effusion can be seen in homozygous embryos