About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfr2tm1.1Nsub
targeted mutation 1.1, V Nathan Subramaniam
MGI:3043773
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfr2tm1.1Nsub/Tfr2tm1.1Nsub involves: 129T2/SvEms MGI:4458423
hm2
 		Tfr2tm1.1Nsub/Tfr2tm1.1Nsub involves: 129T2/SvEms * C57BL/6 MGI:3718692


Genotype
MGI:4458423
hm1
Allelic
Composition		 Tfr2tm1.1Nsub/Tfr2tm1.1Nsub
Genetic
Background		 involves: 129T2/SvEms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfr2tm1.1Nsub mutation (0 available); any Tfr2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age

homeostasis/metabolism
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age
increased liver iron level ( J:160785 )
• at P14 and further at 22 and 52 weeks

liver/biliary system
increased liver iron level ( J:160785 )
• at P14 and further at 22 and 52 weeks

immune system
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age




Genotype
MGI:3718692
hm2
Allelic
Composition		 Tfr2tm1.1Nsub/Tfr2tm1.1Nsub
Genetic
Background		 involves: 129T2/SvEms * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfr2tm1.1Nsub mutation (0 available); any Tfr2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased spleen iron level ( J:114330 )
• significantly decreased
increased circulating iron level ( J:114330 )
• at 10 weeks, mice have elevated transferrin saturation (83.7% compared to 36.7% in wild-type mice)
increased liver iron level ( J:114330 )
• hepatic iron concentration is 5-fold higher (1023 compared to 188.8 ug/g in wild-type mice)
hemochromatosis ( J:114330 )
• the iron staining pattern in hepatocytes is similar to that seen in patients with Tfr2 associated hemochoromatosis

hematopoietic system
decreased spleen iron level ( J:114330 )
• significantly decreased

immune system
decreased spleen iron level ( J:114330 )
• significantly decreased

liver/biliary system
increased liver iron level ( J:114330 )
• hepatic iron concentration is 5-fold higher (1023 compared to 188.8 ug/g in wild-type mice)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory