Phenotypes associated with this allele

• Allele Symbol: S100a4^tm1Amba
• Allele Name: targeted mutation 1, Noona Ambartsumian
• Allele ID: MGI:3043753
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S100a4^tm1Amba/S100a4^tm1Amba	involves: 129S1/Sv * 129X1/SvJ * NMRI	MGI:3043762
hm2	S100a4^tm1Amba/S100a4^tm1Amba	involves: A/Sn	MGI:3043763

Genotype
MGI:3043762

hm1

• Allelic Composition: S100a4^tm1Amba/S100a4^tm1Amba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:89563 )

• while embryonic death was directly identified, the gender ratio was skewed at birth with fewer females being born than males

neoplasm

increased tumor incidence ( J:89563 )

• 10% of all 10 to 14 month old mice exhibited spontaneous tumors

• the tumors were predominantly of epithelial origin, most frequently carcinomas of the lung

• while the tumors were TRP53-positive, they were attributed to functional destabilization of the TRP53

• metastases of lymphoma to the liver was observed, however metastases was not observed in mice with tumors of epithelial origin

increased mammary adenocarcinoma incidence ( J:89563 )

• spontaneous adenocarcinoma type B, composed of solid undifferentiated structures with a minor tubular component

increased hepatocellular carcinoma incidence ( J:89563 )

• spontaneous hepatocellular carcinoma surrounded by severe liver cell dysplasia

increased lymphoma incidence ( J:89563 )

• spontaneous with metastases to the liver

increased lung carcinoma incidence ( J:89563 )

• spontaneous bronchioalveolar carcinomas of solid type, composed of dense tumor masses infiltrating the alveolar spaces with undefined cellular borders and relatively mild nuclear pleomorphism

increased fibrosarcoma incidence ( J:89563 )

• spontaneous fibrosarcoma observed in the uterus of one mouse

integument

increased mammary adenocarcinoma incidence ( J:89563 )

• spontaneous adenocarcinoma type B, composed of solid undifferentiated structures with a minor tubular component

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:89563 )

• spontaneous adenocarcinoma type B, composed of solid undifferentiated structures with a minor tubular component

respiratory system

increased lung carcinoma incidence ( J:89563 )

• spontaneous bronchioalveolar carcinomas of solid type, composed of dense tumor masses infiltrating the alveolar spaces with undefined cellular borders and relatively mild nuclear pleomorphism

liver/biliary system

increased hepatocellular carcinoma incidence ( J:89563 )

• spontaneous hepatocellular carcinoma surrounded by severe liver cell dysplasia

Genotype
MGI:3043763

hm2

• Allelic Composition: S100a4^tm1Amba/S100a4^tm1Amba
• Genetic Background: involves: A/Sn

cellular

abnormal apoptosis ( J:89563 )

• decreased apoptosis in response to gamma-irradiation relative to controls