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Allele Symbol Allele Name Allele ID |
Tg(Amy1TAg)501Knw transgene insertion 501, Barbara Knowles MGI:3043029 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cells from transgenic mice exposed to T antigen respond inefficiently to subsequent immunization with T antigen in T cell transfer experiments
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• T cells from transgenic mice exposed to T antigen respond inefficiently to subsequent immunization with T antigen in T cell transfer experiments
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 6 of 20 mice exhibit visible metastastic nodules in the liver; these consist of the same neoplastic cells and are calcified but contain less osteoid
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• 20 of 30 mice develop osteosarcomas at ~15 months of age; multiple primary tumors involving anatomically distinct bones are noted in >5 of 20 mice
• most tumors originate in the axial skeleton and are found either at the base of the skull, in the vertebral column, shoulder, pelvic girdle, or ribs
• several tumors are found in the proximal humerus or femur whereas the distal bones of the extremities are not involved
• although tumor histology is variable, every tumor contains spindle-shaped cells and larger polygonal and pleomorphic cells with prominent blood vessels and all tumors contain osteoid with varying degrees of calcification; woven bone is noted in some tumors
• a cell line derived from a primary tumor produced osteosarcomas upon transfer into nude mice
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• 20 of 30 mice develop osteosarcomas at ~15 months of age; multiple primary tumors involving anatomically distinct bones are noted in >5 of 20 mice
• most tumors originate in the axial skeleton and are found either at the base of the skull, in the vertebral column, shoulder, pelvic girdle, or ribs
• several tumors are found in the proximal humerus or femur whereas the distal bones of the extremities are not involved
• although tumor histology is variable, every tumor contains spindle-shaped cells and larger polygonal and pleomorphic cells with prominent blood vessels and all tumors contain osteoid with varying degrees of calcification; woven bone is noted in some tumors
• a cell line derived from a primary tumor produced osteosarcomas upon transfer into nude mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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