Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fstl1tm1Nju mutation
(0 available);
any
Fstl1 mutation
(44 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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nervous system
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• small dorsal root ganglion neurons have a reduction in the number of FSTL1-immunoreactive vesicles
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• firing rates are elevated in wide-dynamic range neurons and both innocuous (pressure) and noxious (pinch) stimuli induce a similar increase in firing rate
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• the baseline of spontaneous excitatory postsynaptic current frequency in lamina II neurons is elevated
• the K+ induced frequency is increased
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behavior/neurological
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• reduced response threshold to von Frey mechanical stimuli applied to the hindpaw
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• display exaggerated responses in both first and second phases of the nociceptive reaction after intradermal injection of 0.5% formalin
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• reduced response latencies during radiant heat testing
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation
(0 available);
any
Gabra2 mutation
(34 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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behavior/neurological
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• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scn10a-cre)1Rkun mutation
(0 available)
Tlx3tm2.1Qima mutation
(0 available);
any
Tlx3 mutation
(14 available)
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nervous system
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• at P30 lumbar in the dorsal root ganglion the molecular identity of IB4+ neurons is modified resulting in impaired segregation of TrkA+ and Ret+ neurons
• decrease or absence of expression of genes encoding sensory channels and receptors involved with pain, itch and/or temperature sensation at P30 in the lumbar and thoracic dorsal root ganglia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.1Acsc mutation
(0 available);
any
Kcnt1 mutation
(66 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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behavior/neurological
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• increased mechanical hypersensitivity after spared nerve injury used to induce a neuropathic pain model
• however, inflammatory pain behavior is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycbp2tm1.1Klsc mutation
(0 available);
any
Mycbp2 mutation
(223 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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nervous system
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• the medial region of lamina II is enlarged in the spinal cord compared with wild-type mice
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behavior/neurological
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• mice exhibit prolonged formalin-induced hyperphagia compared with wild-type mice
• however, mice exhibit normal mustard oil-induced desensitization and behavioral response to mechanical stimuli
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation
(0 available);
any
Gabra2 mutation
(34 available)
Gabra2tm2.1Uru mutation
(1 available);
any
Gabra2 mutation
(34 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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behavior/neurological
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• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm2.1Uru mutation
(1 available);
any
Gabra2 mutation
(34 available)
Tg(Scn10a-cre)1Rkun mutation
(0 available)
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nervous system
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• mice treated with DZP and a low concentration of muscimol fail to exhibit a drop in the rate of successful transmission unlike similarly treated wild-type mice
• DZP-potentiated dorsal root potential is strongly reduced compared to in wild-type mice
• however, bicuculline-induced dorsal root potential size and sensitivity
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• the amplitudes of GABAergic membrane currents evoked by DZP are reduced compared to in wild-type mice
• however, muscimol induces normal amplitudes of GABAergic membrane currents
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behavior/neurological
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• DZP-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory thermal and mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic thermal and mechanical nociception is normal
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homeostasis/metabolism
Analysis Tools