Phenotypes associated with this allele

• Allele Symbol: Icam5^tm1(cre)Mmsh
• Allele Name: targeted mutation 1, Masayoshi Mishina
• Allele ID: MGI:3042494
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icam5^tm1(cre)Mmsh/Icam5^tm1(cre)Mmsh	involves: C57BL/6 * CBA	MGI:3043107

Genotype
MGI:3043107

hm1

• Allelic Composition: Icam5^tm1(cre)Mmsh/Icam5^tm1(cre)Mmsh
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:89407 )

• enhanced performance in tests with appetitive reinforcers (radial maze and water-finding tasks) but not in tests with aversive stimuli for conditioning (contextual fear conditioning or Morris water maze)

nervous system

nervous system phenotype ( J:89407 )

N • no detected abnormalities in neural development or synaptic structure

abnormal sensorimotor gating ( J:89407 )

• enhanced prepulse inhibition of the acoustic startle response

enhanced long-term potentiation ( J:89407 )

• increased hippocampal LTP and its saturation level