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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Doc2atm1Ytk
targeted mutation 1, Yoshimi Takai
MGI:3042481
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Doc2atm1Ytk/Doc2atm1Ytk involves: 129P2/OlaHsd * C57BL/6J MGI:3043140
cx2
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg 		involves: 129P2/OlaHsd * C57BL/6 MGI:4440457


Genotype
MGI:3043140
hm1
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal passive avoidance behavior ( J:89423 )
• impairment in the passive avoidance task

nervous system
reduced long-term potentiation ( J:89423 )
• excitatory synaptic responses evoked with 5 Hz stimulation showed a significantly larger frequency facilitation followed by a steeper depression than those in wild-type mice
• basal synaptic transmission is intact




Genotype
MGI:4440457
cx2
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (14 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal miniature excitatory postsynaptic currents ( J:158605 )
• mice exhibit decreased spontaneous release frequency of miniature excitatory postsynaptic current (mEPSC) compared with wild-type mice
• however, expression of Doc2b restores normal mEPSC frequency
decreased neurotransmitter release ( J:158605 )
• average spontaneous release frequency is decreased compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory