Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation
(1 available);
any
Ihh mutation
(22 available)
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
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skeleton
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• growth plate is expanded, however less than in compound heterozygous mice that contain Ihh
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation
(1 available);
any
Ihh mutation
(22 available)
Ihhtm2Amc mutation
(0 available);
any
Ihh mutation
(22 available)
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
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skeleton
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• ectopic hypertrophic differentiation in growth plates, however do not observe elongation of the columnar region
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
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skeleton
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• growth plate is shorted by about 8%
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pthlhtm1Hmk mutation
(0 available);
any
Pthlh mutation
(19 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
Tg(Col2a1-PTHLH)1Ecw mutation
(0 available)
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skeleton
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• increase in tibia length
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• exhibit ectopically differentiated chondrocytes
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• eutopic hypertrophic chondrocyte differentiation is stimulated
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limbs/digits/tail
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• increase in tibia length
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm2Amc mutation
(0 available);
any
Ihh mutation
(22 available)
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
|
|
|
skeleton
|
• elongation of the columnar region
|
|
• ectopic hypertrophic differentiation in growth plates
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
|
|
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skeleton
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• develop ectopic hypertrophy in the columnar region of tibia due to premature hypertrophic differentiation
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• periarticular chondrocyte differentiation into columnar cells is accelerated
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1rtm1Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Pth1rtm2Hmk mutation
(0 available);
any
Pth1r mutation
(28 available)
Tg(Bglap2-cre)1Kry mutation
(0 available)
|
|
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skeleton
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• chondrocytes prematurely differentiate into hypertrophic chondrocytes in the columnar region
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