Phenotypes associated with this allele

• Allele Symbol: Tfap2c^tm1.1Hsc
• Allele Name: targeted mutation 1.1, Hubert Schorle
• Allele ID: MGI:3040993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfap2c^tm1.1Hsc/Tfap2c^tm1.1Hsc	involves: 129P2/OlaHsd	MGI:3040994
ht2	Tfap2c^tm1.1Hsc/Tfap2c^+	involves: 129P2/OlaHsd	MGI:3040995

Genotype
MGI:3040994

hm1

• Allelic Composition: Tfap2c^tm1.1Hsc/Tfap2c^tm1.1Hsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:78934 )

• embryos die between E7 and E9

embryo

decreased embryo size ( J:78934 )

• mutant embryos display significant growth retardation by E7.5 (50-fold smaller than wild-type)

absent mesoderm ( J:78934 )

• mesoderm is not formed; likely due to gastrulation defects

abnormal trophoblast giant cell morphology ( J:78934 )

• in culture, epithelial cell morphology was not maintained over time

decreased trophoblast giant cell number ( J:78934 )

• fewer giant cells were present

small ectoplacental cone ( J:78934 )

• trophoblast cells in the ectoplacental cone did not proliferate

absent placental labyrinth ( J:78934 )

• the labyrinth layer failed to form

growth/size/body

decreased embryo size ( J:78934 )

• mutant embryos display significant growth retardation by E7.5 (50-fold smaller than wild-type)

Genotype
MGI:3040995

ht2

• Allelic Composition: Tfap2c^tm1.1Hsc/Tfap2c⁺
• Genetic Background: involves: 129P2/OlaHsd

growth/size/body

decreased body size ( J:78934 )

• transient at birth; adults reach a size comparable to littermates