All Phenotypes Raf1<tm1Ulb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Raf1^tm1Ulb
targeted mutation 1, Catrin Pritchard
MGI:3040971

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Raf1^tm1Ulb/Raf1^tm1Ulb	involves: 129P2/OlaHsd * C57BL/6	MGI:3046976
hm2	Raf1^tm1Ulb/Raf1^tm1Ulb	involves: 129P2/OlaHsd * MF1	MGI:3046977

Allelic Composition	Raf1^tm1Ulb/Raf1^tm1Ulb
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raf1^tm1Ulb mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 had increased embryonic survival relative to those on a mixed background involving 129P2/OlaHsd and C57BL/6

cardiovascular system

abnormal vasculogenesis ( J:89619 )

absent vitelline blood vessels ( J:89619 )

hemorrhage ( J:89619 )

• observed in ~25% of mutants

cellular

abnormal apoptosis ( J:89619 )

• increased apoptosis throughout the mutant embryos

embryo

absent vitelline blood vessels ( J:89619 )

embryonic growth arrest ( J:89619 )

decreased embryo size ( J:89619 )

abnormal somite development ( J:89619 )

• fewer somites than wild-type

growth/size/body

decreased embryo size ( J:89619 )

decreased body weight ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 were 50 to 60% lighter than those on a mixed background involving 129P2/OlaHsd and C57BL/6

hematopoietic system

anemia ( J:89619 )

liver/biliary system

liver hypoplasia ( J:89619 )

Allelic Composition	Raf1^tm1Ulb/Raf1^tm1Ulb
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raf1^tm1Ulb mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 had increased embryonic survival relative to those on a mixed background involving 129P2/OlaHsd and C57BL/6

embryo

embryonic growth arrest ( J:89619 )

decreased embryo size ( J:89619 )

abnormal somite development ( J:89619 )

abnormal placenta development ( J:89619 )

• small and disorganized

• the spongioblast layer was reduced in size, mesenchymal cells were undifferentiated, and there were fewer blood vessels than in wild-type

growth/size/body

decreased embryo size ( J:89619 )

decreased body weight ( J:89619 )

• mice on a mixed background involving 129P2/OlaHsd and MF1 were 50 to 60% lighter than those on a mixed background involving 129P2/OlaHsd and C57BL/6

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