Analysis Tools
endocrine/exocrine glands
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• in young mice the pancreas becomes uniformly rigid and whitish as interstitial fibrosis occurs
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Allele Symbol Allele Name Allele ID |
Tg(MtTGFA)100Lmb transgene insertion 100, Glenn Merlino MGI:3040889 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in young mice the pancreas becomes uniformly rigid and whitish as interstitial fibrosis occurs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• secretory epithelium cell survival and proliferation is increased during involution compared to in wild-type mice
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• involution is delayed compared to in wild-type mice
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• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction
• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor
• however, no evidence of metastatic lesions is present
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• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas
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• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction
• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor
• however, no evidence of metastatic lesions is present
|
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• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas
|
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• secretory epithelium cell survival and proliferation is increased during involution compared to in wild-type mice
|
|
|
• involution is delayed compared to in wild-type mice
|
|
• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction
• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor
• however, no evidence of metastatic lesions is present
|
|
• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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