Phenotypes associated with this allele

• Allele Symbol: Tg(MtTGFA)100Lmb
• Allele Name: transgene insertion 100, Glenn Merlino
• Allele ID: MGI:3040889
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MtTGFA)100Lmb/Tg(MtTGFA)100Lmb	involves: FVB/N	MGI:3799644
tg2	Tg(MtTGFA)100Lmb/0	involves: FVB/N	MGI:3800167

Genotype
MGI:3799644

tg1

• Allelic Composition: Tg(MtTGFA)100Lmb/Tg(MtTGFA)100Lmb
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

pancreas fibrosis ( J:28452 )

• in young mice the pancreas becomes uniformly rigid and whitish as interstitial fibrosis occurs

Genotype
MGI:3800167

tg2

• Allelic Composition: Tg(MtTGFA)100Lmb/0
• Genetic Background: involves: FVB/N

endocrine/exocrine glands

abnormal mammary gland morphology ( J:72083 )

♀ • secretory epithelium cell survival and proliferation is increased during involution compared to in wild-type mice

abnormal involution of the mammary gland ( J:72083 )

♀ • involution is delayed compared to in wild-type mice

increased mammary gland tumor incidence ( J:72083 )

• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction

• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor

• however, no evidence of metastatic lesions is present

increased mammary adenocarcinoma incidence ( J:72083 )

• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas

neoplasm

increased mammary gland tumor incidence ( J:72083 )

• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction

• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor

• however, no evidence of metastatic lesions is present

increased mammary adenocarcinoma incidence ( J:72083 )

• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas

integument

abnormal mammary gland morphology ( J:72083 )

♀ • secretory epithelium cell survival and proliferation is increased during involution compared to in wild-type mice

abnormal involution of the mammary gland ( J:72083 )

♀ • involution is delayed compared to in wild-type mice

increased mammary gland tumor incidence ( J:72083 )

• by 9 months of age, 62% of female mice develop mammary tumors with or without zinc induction

• mammary gland tumors develop mostly in parous females and only 1 male exhibited a mammary gland tumor

• however, no evidence of metastatic lesions is present

increased mammary adenocarcinoma incidence ( J:72083 )

• by 9 months of age, one third of multiparous females develop mammary adenocarcinomas