Phenotypes associated with this allele

• Allele Symbol: Prm2^tm1Eddy
• Allele Name: targeted mutation 1, Edward M Eddy
• Allele ID: MGI:3039800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prm2^tm1Eddy/Prm2^+	either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N)	MGI:3039836

Genotype
MGI:3039836

ht1

• Allelic Composition: Prm2^tm1Eddy/Prm2⁺
• Genetic Background: either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:69127 , J:89324 )

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:69127)

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:69127)

♂ • DNA in 129 sperm is not as compacted and released more readily than in B6 sperm (J:69127)

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:89324)

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:89324)

♂ • DNA in 129 sperm is not as compacted as in B6 sperm (J:89324)

immotile sperm ( J:69127 )

♂ • 129 sperm from chimeras is immotile

infertility ( J:69127 , J:89324 )

• both male and female chimeras produce only non-agouti (B6) offspring (J:69127)

• male chimeras produce only non-agouti (B6) offspring (J:89324)

abnormal fertilization ( J:69127 , J:89324 )

• sperm derived from spermatogenic cells with one copy of the mutated allele are unable to fertilize eggs (J:69127)

• sperm derived from spermatogenic cells with one copy of the mutated allele are unable to fertilize eggs in vivo (J:89324)

• following intracytoplasmic sperm injection the majority (86%) of eggs fertilized with 129 sperm only reached the 2 to 6 cell stage (J:89324)

cellular

teratozoospermia ( J:69127 , J:89324 )

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:69127)

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:69127)

♂ • DNA in 129 sperm is not as compacted and released more readily than in B6 sperm (J:69127)

♂ • sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:89324)

♂ • chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:89324)

♂ • DNA in 129 sperm is not as compacted as in B6 sperm (J:89324)

immotile sperm ( J:69127 )

♂ • 129 sperm from chimeras is immotile