Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl24Bst mutation
(1 available);
any
Rpl24 mutation
(24 available)
Tg(IghMyc)186Brn mutation
(1 available)
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cellular
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N |
• number of S phase lymphocytes is more normal
• lymphocytes with duplicated centrosomes are eliminated or reduced in number
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• double the number of apoptotic lymphocytes as compared to mice with Tg(IghMyc)186Brn alone
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immune system
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N |
• splenomegaly is reduced
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neoplasm
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N |
• onset of lymphomas is delayed and many mice never develop lymphomas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl38tm1Rugg mutation
(0 available);
any
Rpl38 mutation
(18 available)
Tg(IghMyc)186Brn mutation
(1 available)
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cellular
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N |
• number of S phase lymphocytes is more normal
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• increased cell death in precancerous cells
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neoplasm
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N |
• marked suppression of lymphoma formation
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Allelic
Composition |
Tg(IghMyc)186Brn/0
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Genetic
Background |
involves: C57BL/LiA * CBA/BrA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)186Brn mutation
(1 available)
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cellular
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• large percentage of lymphocytes have duplicated centrosomes
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• increased number of binucleated lymphocytes
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• increased number of B cells in S phase
• defects in cytokinesis
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• increased protein synthesis during mitosis
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Analysis Tools