Phenotypes associated with this allele

• Allele Symbol: Atp8b3^tm1Gar
• Allele Name: targeted mutation 1, David L Garbers
• Allele ID: MGI:3039498
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp8b3^tm1Gar/Atp8b3^tm1Gar	involves: 129S/SvEv * C57BL/6J	MGI:3039525

Genotype
MGI:3039525

hm1

• Allelic Composition: Atp8b3^tm1Gar/Atp8b3^tm1Gar
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:88796 )

• fewer pups born to mutant male mice

reduced male fertility ( J:88796 )

♂

abnormal fertilization ( J:88796 )

• impaired sperm-egg interaction

• normal rates of fertilization rates were observed when spermatozoa were added to zona pellucida-free eggs

• premature exposure of phosphatidylserine on the outer membrane leaflet of spermatozoa

• normal sperm morphology and motility

impaired acrosome reaction ( J:88796 )

♂ • reduced zona pellucida induced acrosome reactions