Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Coll mutation
(0 available);
any
Ccna1 mutation
(28 available)
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cellular
reproductive system
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• combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different
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• spermatozoa are absent from the vas deferens and epididymis instead the lumen of the epididymis contained many degenerating spermatocytes and some giant multi-nucleated cells
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endocrine/exocrine glands
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• combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different
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Allelic Composition |
Ccna1tm1Coll/Ccna1+
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Genetic Background |
either: 129S/SvEv or (involves: 129S/SvEv * MF1) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Coll mutation
(0 available);
any
Ccna1 mutation
(28 available)
|
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reproductive system
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• significantly fewer sperm are recovered from heterozygotes compared to wild-type mice
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• pachytene spermatocytes are unaffected, while the number of haploid spermatids is significantly lower compared to wild-type mice
• Background Sensitivity: this affect is more pronounced on an inbred 129S6/SvEvTac background than on an outbred 129S6/SvEvTac x MF1 background
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• the conception rate was reduced to 16% compared to 90% for wild-type mice
• on an inbred 129S6/SvEv background no offspring were obtained from heterozygous matings
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cellular
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• significantly fewer sperm are recovered from heterozygotes compared to wild-type mice
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