All Phenotypes Calcr<tm1Dgal> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Calcr^tm1Dgal
targeted mutation 1, D L Galson
MGI:3038975

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calcr^tm1Dgal/Calcr^tm1Dgal	Not Specified	MGI:3040610
ht2	Calcr^tm1Dgal/Calcr⁺	Not Specified	MGI:3040611
cx3	Calcr^tm1Dgal/Calcr⁺ Iapp^tm1Sgm/Iapp⁺	involves: 129P2/OlaHsd	MGI:3040612

Allelic Composition	Calcr^tm1Dgal/Calcr^tm1Dgal
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92983 )

• homozygous embryos start dying between E9.5 and E10.5

• no homozygous embryos are found after E10.5

Allelic Composition	Calcr^tm1Dgal/Calcr⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mineral density ( J:88964 )

• due to increased bone formation

increased bone mass ( J:88964 )

increased bone ossification ( J:88964 )

• increase in bone formation rate

• however, bone resorption is normal

Allelic Composition	Calcr^tm1Dgal/Calcr⁺ Iapp^tm1Sgm/Iapp⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcr^tm1Dgal mutation (0 available); any Calcr mutation (59 available)
Iapp^tm1Sgm mutation (2 available); any Iapp mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased osteoclast cell number ( J:88964 )

increased bone mass ( J:88964 )

increased bone ossification ( J:88964 )

• increase in bone formation rate

hematopoietic system

increased osteoclast cell number ( J:88964 )

immune system

increased osteoclast cell number ( J:88964 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24