Phenotypes associated with this allele

• Allele Symbol: nm3
• Allele Name: neurological mutant 3
• Allele ID: MGI:3038126
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nm3/nm3	involves: RIIIS/J	MGI:3038236

Genotype
MGI:3038236

hm1

• Allelic Composition: nm3/nm3
• Genetic Background: involves: RIIIS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:88298 )

• mice do not survive past weaning

behavior/neurological

jerky movement ( J:88298 )

abnormal stationary movement ( J:88298 )

• characteristic choreaform and bradykinetic-type movements typical of Parkinson's Disease

bradykinesia ( J:88298 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:88298 )

N • no morphological changes were observed in the inner ear as would be expected in peripheral vestibular diseases

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:88298 )

N • blood/serum chemistries did not differ from those of unaffected littermates suggesting no overt pathology in liver, bone, pancreatic, gastrointestinal, endocrine, kidney or hematopoietic systems

decreased dopamine level ( J:88298 )

• 15-20% reduction in the level of dopamine in the midbrain

• 15-20% reduction in the level of 3,4-dihydroxyphenylacetic acid (DOPAC), the principle dopamine metabolite, in the midbrain

muscle

muscle phenotype ( J:88298 )

N • no morphological changes were observed in the skeletal muscle as would be expected in neuromuscular degenerative diseases

nervous system

nervous system phenotype ( J:88298 )

N • no morphological changes were observed in the peripheral nervous system or in the brain including the cerebellum, basal ganglia, and striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:88298