Phenotypes associated with this allele
Allelic
Composition |
Emx2Pdo/Emx2Pdo
|
|
Genetic
Background |
involves: BALB/c * C3H/HeN |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2Pdo mutation
(2 available);
any
Emx2 mutation
(23 available)
|
|
|
mortality/aging
|
|
• homozygous animals die shortly after birth
|
hearing/vestibular/ear
|
|
• absence of the articulatory surface for the incus
|
|
|
• a rounded head was observed
|
renal/urinary system
|
|
• reduced size of either the left or right kidney
|
skeleton
|
|
• absence of the articulatory surface for the incus
|
|
|
• a rounded head was observed
|
craniofacial
|
|
• absence of the articulatory surface for the incus
|
|
|
• a rounded head was observed
|
Allelic
Composition |
Emx2Pdo/Emx2+
|
|
Genetic
Background |
involves: BALB/c |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2Pdo mutation
(2 available);
any
Emx2 mutation
(23 available)
|
|
|
hearing/vestibular/ear
|
|
• in the apical and middle turns of the cochlea
|
|
|
• some appearing to form a second row
|
nervous system
|
|
• in the apical and middle turns of the cochlea
|
|
|
• some appearing to form a second row
|
craniofacial
skeleton
Allelic
Composition |
Emx2Pdo/Emx2+
|
|
Genetic
Background |
involves: BALB/c * C3H/HeN |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2Pdo mutation
(2 available);
any
Emx2 mutation
(23 available)
|
|
|
behavior/neurological
|
|
• lack of Preyer reflex, indicating a severe hearing defect
|
cardiovascular system
|
N |
• EEG recordings, gross histology and scanning EM analysis did not reveal any cardiac defects
|
hearing/vestibular/ear
|
|
• defects in the middle ear bones results in rendering the ossicular chain incomplete
(J:89093)
|
|
|
• the incus lacks the lenticular process
|
|
|
• the incus lacks the long process
|
|
|
• the malleus shows a malformed articulatory surface
|
|
|
• the stapes head shows a bobble shape instead of the flat surface seen in controls
|
|
|
• the inner hair cells are disorganized with an increased number of cells noted
(J:89093)
|
|
|
• four rows of outer hair cells are present instead of three; irregular arrangement is also noted; greater numbers of outer hair cells are present
(J:89093)
|
|
|
• an increase in compound action potential threshold was seen
• normal endocochlear potential was also noted, suggesting that stria vascularis function was normal
|
skeleton
|
|
• defects in the middle ear bones results in rendering the ossicular chain incomplete
(J:89093)
|
|
|
• the incus lacks the lenticular process
|
|
|
• the incus lacks the long process
|
|
|
• the malleus shows a malformed articulatory surface
|
|
|
• the stapes head shows a bobble shape instead of the flat surface seen in controls
|
|
|
• defect in the articulatory surfaces between the malleus and the incus was noted
|
|
|
• defect in the articulation between the incus and stapes; no connection between the incus and stapes
|
nervous system
|
|
• the inner hair cells are disorganized with an increased number of cells noted
(J:89093)
|
|
|
• four rows of outer hair cells are present instead of three; irregular arrangement is also noted; greater numbers of outer hair cells are present
(J:89093)
|
|
|
• an increase in compound action potential threshold was seen
• normal endocochlear potential was also noted, suggesting that stria vascularis function was normal
|
craniofacial
|
|
• defects in the middle ear bones results in rendering the ossicular chain incomplete
(J:89093)
|
|
|
• the incus lacks the lenticular process
|
|
|
• the incus lacks the long process
|
|
|
• the malleus shows a malformed articulatory surface
|
|
|
• the stapes head shows a bobble shape instead of the flat surface seen in controls
|
Allelic
Composition |
Emx2Pdo/Emx2tm1Pgr
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C3H/HeN * C57BL/6 |
|
|
|
mortality/aging
|
|
• homozygous animals die shortly after birth
|
hearing/vestibular/ear
renal/urinary system
|
|
• reduced size of either the left or right kidney
|
skeleton
craniofacial
Analysis Tools