About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata1tm6Sho
targeted mutation 6, Stuart Orkin
MGI:3037864
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata1tm6Sho/Gata1tm6Sho C.129S1-Gata1tm6Sho MGI:5316007
hm2
 		Gata1tm6Sho/Gata1tm6Sho involves: 129S1/Sv MGI:3037966
hm3
 		Gata1tm6Sho/Gata1tm6Sho involves: 129S1/Sv * BALB/c MGI:4847667
ot4
 		Gata1tm6Sho/Y involves: 129S1/Sv MGI:3037970


Genotype
MGI:5316007
hm1
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 C.129S1-Gata1tm6Sho
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin (to induce allergic skin inflammation) compared to wild-type mice
• eosinophils are not detectable in skin of EC-sensitized mutants with OVA, however dermal infiltration by CD4+ cells is similar to wild-type mice and systemic immune response to EC sensitization with OVA is comparable to wild-type controls

integument
abnormal skin physiology ( J:182213 )
• mutants exhibit impaired epidermal and dermal thickening and collagen deposition in OVA-sensitized skin (to induce allergic skin inflammation) compared to wild-type mice




Genotype
MGI:3037966
hm2
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:88711 )
N
• all other hematopoietic lineages are normal
• mutants are viable, fertile and have no gross abnormalities
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent

immune system
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent




Genotype
MGI:4847667
hm3
Allelic
Composition		 Gata1tm6Sho/Gata1tm6Sho
Genetic
Background		 involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:92849 )
N
• methacholine induced airway hypersensitivity is unaffected
abnormal bronchiole morphology ( J:92849 )
• reduced extracellular matrix deposition in bronchioles after allergen challenge
• also in perivascular regions
abnormal respiratory system physiology ( J:92849 )
• reduced mucus production after Aspergillus fumigatus exposure
• airway smooth muscle proliferation does not occur in response to allergen

hematopoietic system
abnormal leukocyte cell number ( J:115273 )
• impaired recruitment into bronchoalveolar lavage fluid generally
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
increased neutrophil cell number ( J:115273 )
• three fold increase in airway neutrophilia after Aspergillus fumigatus exposure
decreased lymphocyte cell number ( J:115273 )
• 50% lymphocyte reduction in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure

immune system
abnormal leukocyte cell number ( J:115273 )
• impaired recruitment into bronchoalveolar lavage fluid generally
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
increased neutrophil cell number ( J:115273 )
• three fold increase in airway neutrophilia after Aspergillus fumigatus exposure
decreased lymphocyte cell number ( J:115273 )
• 50% lymphocyte reduction in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
decreased circulating interleukin-13 level ( J:115273 )
• after Aspergillus fumigatus exposure
decreased circulating interleukin-4 level ( J:115273 )
• after Aspergillus fumigatus exposure

homeostasis/metabolism
decreased circulating interleukin-13 level ( J:115273 )
• after Aspergillus fumigatus exposure
decreased circulating interleukin-4 level ( J:115273 )
• after Aspergillus fumigatus exposure
abnormal hemostasis ( J:115273 )
• more modest increase in coagulation components after allergen stimulation than seen in controls




Genotype
MGI:3037970
ot4
Allelic
Composition		 Gata1tm6Sho/Y
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm6Sho mutation (4 available); any Gata1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:88711 )
N
• mast cell production in the bone marrow is normal
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent
decreased erythrocyte cell number ( J:88711 )
• erythrocyte number is reduced by 27% in males
decreased hematocrit ( J:88711 )
• hemoglobin level is reduced in proportion with the reduction in erythrocyte number

immune system
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males
decreased eosinophil cell number ( J:88711 )
• eosinophils are absent

growth/size/body
enlarged spleen ( J:88711 )
• modest splenomegaly is seen in males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory