hematopoietic system
• decreased numbers of invariant natural killer (iNKT) cells in thymus, spleen and liver
• 50% decreased iNTK cell numbers compared to NOD mice
• 70%-75% decreased iNKT cell numbers compared to C3H/HeJ mice
• decreased iNKT cell proportions in pancreas infiltrates compared to NOD animals
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immune system
• decreased numbers of invariant natural killer (iNKT) cells in thymus, spleen and liver
• 50% decreased iNTK cell numbers compared to NOD mice
• 70%-75% decreased iNKT cell numbers compared to C3H/HeJ mice
• decreased iNKT cell proportions in pancreas infiltrates compared to NOD animals
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• decreased IFN-gamma secretion after induced cytokine production (46% of IFN-gamma secretion levels in NOD mice)
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• decreased IL-4 secretion after induced cytokine production (38% of IL-4 secretion levels in NOD mice)
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